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KMID : 1036520120020010022
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Clinical Neuro-Ophthalmology
2012 Volume.2 No. 1 p.22 ~ p.26
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Disorders of Conjugate Gaze
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Lee Seung-Han
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Abstract
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Disorders of conjugate gaze are inabilities to move both eyes in a single horizontal or vertical direction. Those of the key structures controlling conjugate horizontal gaze are the paramedian pontine reticular formation (PPRF) and the adjacent abducens nucleus into which a final command are integrated. Pontine lesions affecting the PPRF and/or the abducens nucleus can cause loss of horizontal gaze ipsilateral to the lesion. Cerebral hemispheric lesion can cause conjugate gaze palsy toward the healthy side. Vertical gaze depends on input from fiber paths that ascend from the vestibular system through the MLF on both sides to the 3rd and 4th cranial nerve nuclei, the interstitial nucleus of Cajal (INC), and the rostral interstitial nucleus of the MLF (riMLF). Vertical gaze palsies commonly result from midbrain lesions. Dorsal midbrain syndrome, one of common conjugate up-gaze palsies, may result from a pineal tumor or a tumor or infarct of the midbrain pretectum. This syndrome is characterized by impaired upward gaze, lid retraction, downward gaze preference, convergence-retraction nystagmus, and light-near dissociation.
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KEYWORD
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Conjugate gaze palsy, Paramedian pontine reticular formation, Abducens nucleus, Dorsal midbrain syndrome
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FullTexts / Linksout information
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Listed journal information
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